相关实验视频

Updated: Jun 21, 2025

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
08:03

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation

Published on: October 20, 2022

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在考虑个体间的变异性的情况下,开发制药心脏毒性评估系统

Ali Ikhsanul Qauli1,2, Rakha Zharfarizqi Danadibrata1, Aroli Marcellinus1

  • 1Department of IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea.

Translational and clinical pharmacology
|July 8, 2024
PubMed
概括

这项研究探讨了心脏细胞的个体差异如何影响药物安全性预测. 将这种可变性纳入计算机模型可以改变罕见副作用的预测风险,例如torsade de pointes (TdP).

关键词:
毒性药物毒性 毒性药物毒性在 silico 模拟.个体间的生物学变异这就是Torsades de Pointes的意义.

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Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
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