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重复前列腺特异性抗原检测改善了在磁共振成像后进行前列腺活检的基于风险的男性选择
Petter Davik1,2, Mattijs Elschot3,4, Tone Frost Bathen3,4
1Department of Urology, St. Olav's Hospital, Trondheim, Norway.
European urology open science
|July 8, 2024
概括
重复前列腺特异性抗原 (PSA) 测试改善了接受MRI和活检怀疑前列腺癌的男性的风险分层. PSA 的下降表明风险较低,而增加表明临床上重大疾病的风险较高.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 前列腺癌 (PCa) 诊断依赖于前列腺特异抗原 (PSA) 测试和成像.
- 使用重复PSA测试,但其在风险分层的价值与磁共振成像 (MRI) 和活检一起是有争议的.
研究的目的:
- 评估重复PSA检测是否会增加疑似PCa的男性进行MRI和向活检的风险分层.
- 为了确定PSA变化是否改善预测模型和活检决策策略.
主要方法:
- 在MRI和活检之前,对601名男性进行了至少两次PSA测试的回顾性分析.
- 评估PSA变化作为临床显著PCa (csPCa) 的预测因子,使用多变量逻辑回归.
- 开发并验证了一种MRI-RC模型和一个包含PSA变化的二分体活检决策策略.
主要成果:
- 反复PSA的降低显著降低了csPCa风险 (OR 0.3; P < 0.001).
- 重复PSA的增加显著增加了cspca的风险 (OR2.97;P<0.001).
- 整合PSA变化改善了MRI-RC模型和活检决策策略的预测性能.
结论:
- 重复PSA测试在MRI和针对PCa的生物检查中提供了有价值的预测信息.
- 包括PSA变化提高了预测模型和临床实用性,可能减少不必要的活检.
关键词:
磁共振成像技术 磁共振成像技术预测模型的预测模型.前列腺腺癌前列腺腺癌.前列腺癌是什么意思 前列腺癌是什么意思前列腺特异抗原的前列腺特异抗原.重复测试重复测试进行.风险计算器风险计算器风险模型风险模型有针对性的活检.更多相关视频
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