体重变化模式与与肥胖相关的复杂多病症之间的联系:来自NHANESES的证据
Hong-Jian Gong1, Xingyao Tang2, Jian-Bo Zhou1
1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Frontiers in endocrinology
|July 8, 2024
概括
在整个成年期保持健康体重,尤其是在中年,对于预防晚年慢性疾病至关重要. 稳定的肥胖症显著增加了老年发展多种健康状况的风险.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 老年学是指老年学的学科.
背景情况:
- 肥胖是非传染性疾病 (NCD) 的首要危险因素,非传染性疾病是导致死亡的主要原因.
- 了解身体质量指数 (BMI) 变化的长期影响对于公共卫生战略至关重要.
研究的目的:
- 调查成人BMI变化与老年人肥胖相关多病症风险之间的关联.
- 评估BMI轨迹对主要慢性疾病的预测能力.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (1999-2018) 中对15520名参与者的回顾性分析.
- 体重指数被分为体重不足,正常体重,超重和肥胖.
- 对BMI变化模式和健康结果 (高血压,癌症,COPD,心血管疾病,糖尿病) 进行评估的几率比率 (OR) 和人口归因分数 (PAF).
主要成果:
- 稳定的肥胖与发展至少一种慢性疾病的最高风险有关 (ORs从2.49到2.90不等).
- 在不同成年时期,从非肥胖到肥胖的体重增加增加了慢性疾病的风险 (ORs 1.62-1.87).
- 中年肥胖症解释了8.6%的老年人的慢性疾病发生.
结论:
- 保持稳定的健康体重,并在成年早期和中年达到减肥,对于健康的衰老至关重要.
- 需要加强战略和政策,以有效地减少肥胖的流行率,并减轻其长期健康后果.
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