中性粒细胞-淋巴细胞比率作为潜在的阿尔茨海默氏症疾病早期标志物
Carlo Cervellati1, Dario Pedrini1, Pietro Pirro1
1Department of Translational Medicine and for Romagna University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy.
Mediators of inflammation
|July 8, 2024
概括
中性粒细胞-淋巴细胞比率 (NLR) 在轻度认知障碍和阿尔茨海默病中升高,但它不能预测疾病的进展. 这种炎症标志物显示出诊断早期痴呆阶段的潜力.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 炎症和免疫失调是痴呆症的关键特征,特别是阿尔茨海默病 (AD).
- 中性粒细胞-淋巴细胞比率 (NLR) 是系统性炎症的一个易于获得的指标.
- 研究NLR的作用可以为认知衰退提供新的诊断和预测见解.
研究的目的:
- 评估中性粒细胞-淋巴细胞比率 (NLR) 在痴呆症中的诊断和预测潜力.
- 为了比较不同认知状态的NLR水平:阿尔茨海默病 (AD),记忆力轻度认知障碍 (aMCI),血管痴呆症 (VAD) 和健康对照.
主要方法:
- 为了测量103名AD患者,212名aMCI患者,34名VAD患者和61名对照患者的NLR,分析了血液样本.
- 一组112名aMCI患者被跟踪36个月,以评估认知变化.
- 采用多变量物流分析来确定NLR和诊断之间的关联.
主要成果:
- 与对照组相比,aMCI和AD患者的NLR显著更高.
- 升高的NLR与aMCI (OR:2.58) 和AD (OR:3.13) 诊断的可能性增加有关.
- 在稳定和进展的aMCI患者之间,NLR没有区别,在VAD中也没有显著升高.
结论:
- 在轻度认知障碍和阿尔茨海默病中,NLR显著增加,这表明其作为生物标志物的潜力.
- NLR没有证明从aMCI转换为AD的预测价值.
- 需要进一步的大规模研究来证实NLR在诊断和监测aMCI和AD中的实用性.
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