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高压氧化疗结合类固醇治疗对突然神经感官听力损失的临床影响:一个病例对照研究

Naoya Sanda^1,2, Michi Sawabe^1,2, Kayoko Kabaya²

¹Department of Otorhinolaryngology Toyota Kosei Hospital Toyota Japan.

Laryngoscope investigative otolaryngology

|July 8, 2024

概括

将高压氧气疗法 (HBOT) 添加到标准的皮质类固醇治疗中,显著改善了突然感觉神经听力损失 (SSNHL) 患者的听力结果. 这种组合疗法为SSNHL患者更好的听力恢复提供了有希望的方法.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
高压医学的高压医学.
听力学听力学是指听力学.

背景情况:

突然感觉神经听力损失 (SSNHL) 是一种需要及时有效治疗的危急病.
标准治疗通常涉及全身皮质类固醇,但结果可能是可变的.
高压氧气疗法 (HBOT) 已被探索为各种低氧条件的辅助疗法.

研究的目的:

评估高压氧化疗 (HBOT) 与系统性皮质类固醇联合用于突然神经感官听力损失 (SSNHL) 的临床疗效.
为了比较SSNHL患者接受HBOT加上皮质类固醇治疗的听力改善与仅接受皮质类固醇治疗 (非HBOT) 的患者.

主要方法:

在三个日本医疗中心进行了一项病例控制研究,涉及298名SSNHL患者 (2020-2023年).
纳入标准包括首次出现的SSNHL,世卫组织3-4级听力损伤,并在症状出现后14天内开始治疗.
听力改善的评估是使用纯色调听力测量方法进行的,并使用治疗权重的逆概率 (IPTW) 方法进行分析.

主要成果:

与非HBOT组 (68名患者) 相比,HBOT组 (67名患者) 的听力改善明显更大 (7.6dB).
在HBOT组中没有头的患者经历了相当大的听力增长 (11.5dB).
在HBOT组,完全听力恢复的可能性显著更高 (OR 2.57).

结论:

与HBOT和全身皮质类固醇的联合治疗在SSNHL患者中显著改善了听力结果,与非HBOT治疗相比.
对于特定的SSNHL患者亚组,HBOT可能是标准护理的宝贵补充.
进一步的研究可以探索SSNHL管理的最佳HBOT协议.

关键词:

案例控制研究研究.高压氧气疗法 (hyperbaric oxygen therapy) 是一种高压氧气疗法.普雷迪尼索隆 (prednisolone) 是一种药物.突然的感觉神经神经听力损失.

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