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突触可塑性对多发性硬化症患者功能衰退的预测值

Carolin Balloff^1,2, Lisa Kathleen Janßen¹, Christian Johannes Hartmann^1,3

¹Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.

Frontiers in neurology

|July 8, 2024

概括

四脉冲 (QPS) 诱导的突触可塑性可能预测多发性硬化症 (MS) 患者的功能衰退. 较低的基线可塑性与手动灵巧度和视觉空间记忆的下降相关,这表明它在MS进展中的作用.

科学领域:

神经科学是一个神经科学.
临床神经学临床神经学
神经康复疗法神经康复疗法

背景情况:

四脉冲 (QPS) 诱导的突触可塑性以前与多发性硬化症 (MS) 患者的认知和运动功能有关.
与健康对照组 (HCs) 相比,在MS患者中没有发现这种可塑性减少.

研究的目的:

研究QPS诱导的突触可塑性与MS中运动和认知障碍的进展之间的关联.
为了确定基线可塑性降低是否预测MS患者的功能衰退.

主要方法:

在80名MS患者和69名HC患者中评估了QPS诱导的可塑性.
每年对运动,认知功能和残疾进行监测,平均为2年.
统计分析包括线性混合效应模型和Cox比例危险模型.

主要成果:

多发性硬化症患者的手动敏捷性或视觉空间记忆力下降,显著降低了基线突触可塑性.
基线可塑性预测视觉空间学习和记忆的下降 (AUC=0.85).
在随访期间,在队列中没有观察到总体临床相关的功能变化.

结论:

由QPS引起的突触可塑性可能与MS的临床显著功能下降有关.
需要进一步的研究,以更长的随访时间和更高的下降率.
认知表现的变化凸显了对强有力的神经心理测试的需求.

关键词:

疾病的进展疾病的进展功能性衰退功能性衰退多发性硬化症多发性硬化症四重冲动刺激的四重冲动刺激重复的跨脑磁性刺激是重复性的.突触性可塑性突触性可塑性

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