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关于口腔平坦和状形性病变的争议
Ilena S Yim1,2, Lewei Zhang1,2,3, Iris Lin1,2
1Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
概括
口腔平坦 (OLP) 和状形 (LD) 是具有恶性潜力的免疫媒介疾病. 由于恶性转变和诊断不一致的风险,OLP和LD都需要仔细考虑.
科学领域:
- 口腔病理学 口腔病理学
- 免疫皮肤学 免疫皮肤学
- 在瘤学瘤学.
背景情况:
- 口腔平坦 (OLP) 是一种免疫介导的疾病,其特征是慢性炎症.
- 世界卫生组织将OLP归类为潜在恶性,恶性转变通常与表现出状和失塑性特征 (LD) 的病变有关.
研究的目的:
- 审查围绕OLP和LD的挑战和复杂性,重点关注它们的恶性潜力,分类以及炎症和发育不良之间的病因关系.
- 强调在OLP和LD中需要标准化诊断标准.
主要方法:
- 使用PubMed,CINAHL和Google Scholar进行了全面的文献搜索,以查找关于OLP,LD和发育不良的英语全文文章.
- 三十六个相关出版物,包括原创研究,评论和元分析,被选为本次审查.
主要成果:
- 研究表明,OLP具有很小但显著的恶性潜力.
- 无论是否呈现有状体特征的LD病变,也被认为是潜在的癌症.
- 在LD的分类和分类方面存在重大分歧,术语和诊断标准不一致.
- 在LD中,液状体炎症和发育不良之间的确切因果关系尚不清楚.
- OLP和LD的组织学诊断受到主观性和不一致的影响,导致观察者间和观察者内部的诊断变化.
结论:
- 无论是OLP还是LD都应视为潜在的恶性疾病,并应谨慎管理.
- 进一步的研究对于阐明OLP和LD的病原性以及建立可靠的诊断标准至关重要.
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