在NHANES 2003-2018年人口中,系统性免疫炎症指数和糖尿病之间的关联
Yufeng Yan1, Hongjing Lu1, Yaguo Zheng1
1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210008, Jiangsu, China.
Journal of the Endocrine Society
|July 8, 2024
概括
高系统性免疫炎症指数 (SII) 水平增加患糖尿病 (DM) 的风险. 升高的SII还与DM和非DM个体的较高死亡率相关.
科学领域:
- 临床医学 临床医学
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 系统性免疫炎症指数 (SII) 是反映系统性炎症的标志物.
- 糖尿病是一种严重的全球健康问题,具有复杂的病因因素.
- 了解DM风险和预后的新生物标志物对于患者的治疗结果至关重要.
研究的目的:
- 调查SII与DM患病率之间的关联.
- 评估SII对患有和没有DM的个体死亡风险的影响.
主要方法:
- 来自全国健康和营养检查调查 (NHANES) 的数据分析,其中有9643名参与者.
- 后勤回归模型来评估SII和DM之间的联系.
- 考克斯比例危险模型,受限立方线和卡普兰-梅尔曲线用于分析SII和死亡率.
主要成果:
- 较高的SII水平显著与患DM的可能性增加有关 (OR,1.31;P = .003).
- 在所有组中,增加的SII与所有原因的死亡率有积极的关联.
- 对SII和死亡率的危险比为1.53 (总),1.61 (DM) 和1.41 (非DM).
- 在DM患者中观察到SII和死亡率之间的线性相关性;在其他人中非线性.
结论:
- 升高的SII是DM发展风险增加的预测因素.
- 患有DM和较高SII水平的个体面临着显著增加的死亡风险.
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