威斯康星州儿童和青少年的非结核性菌根感染
Bryan J Vonasek1, Danièle Gusland2, Julie Tans-Kersten3
1Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
概括
儿童非结核菌菌 (NTM) 感染很常见,特别是在女性中,皮肤和软组织感染最常见. 这项研究发现,在威斯康星州的种族或社会经济群体之间,NTM感染率没有显著差异.
科学领域:
- 儿童传染病 儿童传染病
- 流行病学 流行病学
- 菌根菌感染 菌根菌感染
背景情况:
- 儿童非结核菌 (NTM) 感染缺乏全面的流行病学数据.
- 了解儿科患者中NTM感染模式对于公共卫生至关重要.
- 这项研究解决了在儿童中更好地描述NTM流行病学的需要.
研究的目的:
- 估计威斯康星州儿童和青少年中NTM感染的发生率.
- 确定不同NTM病原体引起的感染的频率和类型.
- 调查NTM感染与种族/种族和社会劣势之间的关联.
主要方法:
- 对18岁以下 (2011-2018) 威斯康星州居民NTM感染报告的回顾性队列研究.
- 对人口统计数据的分析,包括面积贫困指数 (ADI) 的社会劣势.
- 从报告的隔离物种中列出NTM物种和标本类型.
主要成果:
- 在212名儿科患者中发现了224个NTM隔离物;中位数年龄为3岁,55%是女性.
- 最常见的病原体是Mycobacterium avium复合体 (MAC) (69%),大多数感染 (52%) 影响皮肤和软组织.
- 在种族群体或ADI得分之间没有观察到累积发病率的显著变化,除了多种族个体的发病率较低.
结论:
- 儿科NTM感染流行病学显示,女性的发病率更高,皮肤/软组织感染占主导地位,与之前的报告一致.
- 在这个队列中,在种族/民族或社会经济群体之间没有显示出疾病负担的显著差异.
- 建议对更大,更多样化的群体进行进一步的研究,以探索潜在的差异.
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