血管炎中的血栓形成:关于病因学,病理生理学和治疗的最新综述
Kai Zhu1, Feng Lv1, Xiangqian Hou1
1Department of Vascular Surgery, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou City, 2530000, China.
Heliyon
|July 8, 2024
概括
血栓塞栓性疾病是血管炎的并发症,在活跃疾病期间风险增加. 免疫抑制在血管炎患者的静脉血栓症管理方面表现有前途.
科学领域:
- 类风湿病学 类风湿病学
- 血管医学 血管医学
- 免疫学 免疫学 免疫学
背景情况:
- 血栓塞栓性疾病经常复杂化系统性炎症状况,如血管炎.
- 连接血管炎与血栓形成的确切机制仍然不完全理解.
- 炎症性血栓是贝希特综合征 (BS),抗中性粒细胞抗体 (ANCA) 相关的血管炎 (AAV) 和巨细胞动脉炎 (GCA) 的公认症状.
研究的目的:
- 系统地审查最近关于BS,AAV和中/大血管血管炎中血栓栓塞并发症的病因学,病理生理学和治疗的发现.
- 阐明活跃血管性疾病与血栓栓塞事件发生率之间的关系.
- 探索治疗策略,包括免疫抑制,用于控制血管炎中的血栓形成.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,MEDLINE等) 中进行全面的文献搜索. 对于英语文章来说.
- 包括2023年6月之前发表的相关论文的全文.
- 标题和摘要的双重独立审查,与第三位仲裁员进行争议解决.
主要成果:
- 系统性炎症性疾病,特别是血管炎,与静脉和动脉血栓形成的风险增加有关.
- 抗中性粒细胞体抗体 (ANCA) 相关血管炎 (AAV) 显示,血栓栓塞性疾病发病率显著增加,特别是在活跃阶段.
- 有证据表明,免疫抑制是血管炎患者静脉血栓形成的可行管理方法.
结论:
- 血管炎显著增加血栓栓塞事件的风险,影响静脉和动脉系统.
- 活跃的血管疾病是高血栓风险的关键时期.
- 免疫抑制疗法越来越多地被认为有助于在血管炎的背景下控制血栓形成.
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