新型抗炎铁电荷转移复合物的合成,表征和评估
Mervette El Batouti1, E H El-Mossalamy2, Nouf Al-Harby3
1Chemistry Department, Faculty of Science, Alexandria University, Egypt.
Heliyon
|July 8, 2024
概括
通过在绿色溶剂中使用希夫基联体合成新的抗炎铁复合物. 这些复合物表现出强大的抗微生物和抗炎活性,以及自由基清除特性.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 新型抗炎药物的开发至关重要.
- 绿色化学方法对于可持续合成越来越重要.
- 铁复合物具有潜在的治疗应用.
研究的目的:
- 为了合成和表征新的抗炎铁复合物.
- 研究这些复合物的抗微生物和抗炎活性.
- 探索它们的自由基清除能力.
主要方法:
- 合成一个 thiophene-电子供体的希夫基联结体.
- 在绿色溶剂中使用阳离子表面活性剂制备铁 (III) 电荷转移复合物 (Fe-CTC).
- 使用CNH分析,NMR (1H,13C),计算化学 (DFT-B3LYP),UV-Vis,IR/拉曼光谱,元素分析和EDS进行结构确认.
- 在体外和动力学研究用于生物活性评估.
主要成果:
- 成功合成了三种新的抗炎铁复合物.
- Fe-CTCs表现出强大的度依赖的抗微生物和良好的抗炎活性.
- 这些复合体表现出显著的自由基清除活性 (氧化).
- 结构分析证实了铁和体的异质原子 (N,S,O) 之间强大的结合,Fe (III) 离子处于扭曲的八面体几何结构中.
结论:
- 合成的Fe-CTC具有显著的治疗潜力.
- 绿色合成方法在制备新型生物活性铁复合物方面是有效的.
- 该研究强调了抗炎和抗微生物特性的结构-活性关系.
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