基于临床生物标志物的生物衰老和良性前列腺增生风险:一项大型前性队列研究
Qiao Huang1,2, Bing-Hui Li1,2, Yong-Bo Wang1,2
1Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan University Wuhan China.
Aging medicine (Milton (N.S.W))
|July 8, 2024
概括
生物衰老,而不仅仅是时间的年龄,是良性前列腺增生症 (BPH) 的重要危险因素. 缓慢生物衰老的干预措施可能会降低BPH风险和进展.
科学领域:
- 老年病学和泌尿病学
- 生物标志物发现发现
- 流行病学 流行病学
背景情况:
- 慢性年龄 (CAge) 是良性前列腺增生症 (BPH) 的已知危险因素.
- 将生物年龄 (BAge) 和加速衰老 (AAge) 与BPH联系在一起的证据有限.
- 了解衰老对BPH的影响对于疾病管理至关重要.
研究的目的:
- 调查CAge,BAge和AAge与发生BPH风险的关联.
- 在一个大型前性队列中评估多个BAge和AAge措施.
- 确定加速衰老是否是BPH的独立风险因素.
主要方法:
- 利用了来自135,933名在基线没有BPH的男性的英国生物库数据.
- 计算了三种BAge测量 (KDM,PhenoAge,HD) 和两种AAge测量 (KDM-AAge,PhenoAge-AAge) 的时间.
- 采用了Cox的比例危险模型来分析与BPH事件的关联,平均随访时间为13.15年.
主要成果:
- 两个先进的CAge和BAge措施都与增加的BPH风险有关,表现出值效应.
- 在AAage测量和BPH风险之间观察到非线性关系.
- 加速衰老 (AAge > 2 SD) 显著增加了BPH风险 (HR 1.115-1.180),特别是在年轻男性 (<50岁) 和那些水平较低的人群中.
结论:
- 生物衰老是BPH的独立和可修改的风险因素.
- 通过健康干预来减缓生物衰老,可以缓解前列腺衰老并减少BPH负担.
- 这项研究强调了评估BPH风险分层中的生物衰老的重要性.
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