休时间的久坐行为,体力活动和阻塞性睡眠呼吸暂停之间的因果关系:双向的门德尔随机化研究
Haonan Tian1, Aozhe Wang1, Han Wu1
1Department of Exercise Physiology, Beijing Sport University, Beijing, China.
Frontiers in public health
|July 8, 2024
概括
休地看电视和使用电脑会增加阻塞性睡眠呼吸暂停 (OSA) 的风险,而充满活力的体力活动 (VPA) 可能会防止它. OSA不会因果关系地影响久坐的行为或身体活动水平.
科学领域:
- 遗传学 遗传学 是一个
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,静坐行为 (LSB),体力活动 (PA) 和阻塞性睡眠呼吸暂停 (OSA) 之间存在联系.
- 仍然不清楚LSB/PA和OSA发病率之间的因果关系.
- 门德尔随机化 (MR) 可以调查对LSB/PA的遗传倾向及其对OSA的因果影响.
研究的目的:
- 确定休时间的久坐行为 (LSB) 和体力活动 (PA) 对阻塞性睡眠呼吸暂停 (OSA) 风险的因果关系.
- 调查OSA对LSB和PA的潜在因果影响.
- 使用双向双样本门德尔随机化 (MR) 进行强大的因果推理.
主要方法:
- 对于LSB和PA的遗传数据来自英国生物银行;OSA数据来自FinnGen.
- 逆方差加权 (IVW) 是主要的MR分析方法,支持加权中位数和MR-Egger.
- 敏感性分析包括Cochran的Q,MR-Egger拦截,MR-PRESSO和离开一个测试,以确保结果的有效性.
主要成果:
- 基因预测的电视观看和电脑使用显著增加了OSA风险 (OR分别为1.38和1.48).
- 强烈的体力活动 (VPA) 显示出对OSA (OR 0.33) 的潜在保护作用.
- 对于驾驶,中度至强烈的PA或影响LSB/PA的OSA没有发现显著的因果关系.
结论:
- 休时间观看电视和使用电脑被确定为OSA的危险因素.
- 强烈的体力活动 (VPA) 可能是对OSA的保护因素.
- 建议包括减少屏幕时间和增加VPA以减轻OSA风险.
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