在机械通风的重症监护病房患者中,经过活检证明的胃病理发现
Elvan Tekir Yılmaz1, Bilge Olgun Keleş1
1Anesthesiology and Reanimation, Giresun University the Faculty of Medicine, Giresun, TUR.
Cureus
|July 8, 2024
概括
在机械通风 (MV) 重症监护室 (ICU) 患者中,Helicobacter pylori (H. pylori) 的活性比一般人群低. 这表明ICU患者不会面临与H. pylori相关的前恶性胃病变的风险增加.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 杆菌 (H. pylori) 感染是一个全球性的健康问题,与胃潰瘍疾病和出血有关.
- 在重症监护室 (ICU) 中的重症患者可能由于各种因素而患出血的风险增加.
- 在ICU内机械通风 (MV) 患者中,H. pylori的流行和激活需要进一步调查.
研究的目的:
- 为了确定MV患者在ICU中的H. pylori的激活状态.
- 为了比较MVICU患者和呈现消化不良症状的一般患者群体之间的H. pylori激活率.
主要方法:
- 一项回顾性研究分析了79名患者,他们在2023年1月至6月期间接受了食管胃管腺镜检查和组织病理样本采集.
- 患者被分为两个组:35名在ICU的MV患者 (E_MV) 和44名患有腹症状的患者 (E_D).
- 人口统计数据,实验室参数和活检结果记录了H. pylori阳性,肠道转化和缩,并在组之间进行了比较.
主要成果:
- 虽然年龄和性别分布相似,但MV患者的血红蛋白 (Hb) 和血红素 (Htc) 水平与消化不良组相比显著降低.
- 一些实验室参数,包括白细胞 (WBC) 计数,葡萄糖,尿素和C反应蛋白 (CRP),在MV组显著更高.
- 在MV组中,H. pylori阳性明显较低 (11.4%),相比于消化不良组 (31.8%) (p=0.032).
结论:
- 与一般人群相比,机械通风ICU患者中H. pylori激活的患病率明显较低.
- 研究组之间,缩性胃炎和肠道代塑性发病率是可比的.
- 这些发现表明,在ICU中的重症,MV患者似乎没有增加与H. pylori感染相关的胃前恶性病变的风险.
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