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嗅觉康复对冠状病毒后疾病嗅觉功能障碍的恢复的影响:随机对照试验

Alex Zxi Jian Ho¹, Nur Izzati B Ishak², Eugene Hung Chih Wong²

¹Department of Otorhinolaryngology, International Islamic University Malaysia, Kuantan, MYS.

|July 8, 2024

概括

与没有治疗相比,嗅觉训练和鼻喷雾剂在COVID-19感染后没有显著改善嗅觉功能障碍. 对于有效的COVID-19后嗅觉康复策略,需要进一步的研究.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
传染性疾病传染性疾病
神经学神经学

背景情况:

持续的嗅觉功能障碍是COVID-19的常见后果,影响生活质量.
关于管理COVID-19后的气味损失的研究有限,特别是在东南亚.

研究的目的:

评估马来西亚COVID-19后嗅觉功能障碍的嗅觉康复和局部皮质类固醇.
确定影响COVID-19后嗅觉恢复的因素.

主要方法:

马来西亚成年人患有COVID-19后持续的嗅觉丧失被随机分为三个组:嗅觉训练,用mometasone furoate鼻喷雾进行嗅觉训练和对照组.
在六个月的时间内,使用顶级国际嗅觉识别测试 (TIBSIT) 和电子嗅觉问卷 (eODQ) 评估了嗅觉功能.

主要成果:

所有组在六个月的时间里,嗅觉识别 (TIBSIT) 和生活质量 (eODQ) 得分均显著改善.
鼻喷雾加上嗅觉训练组在三个月后比对照组显示出更高的TIBSIT分数,但这种差异在六个月后不再持续.
与对照组相比,单独的嗅觉训练并没有产生统计学上显著的改善.

结论:

六个月后,嗅觉训练和局部皮质类固醇组合都没有在治疗COVID-19后嗅觉功能障碍方面比对照组表现出优越性.
虽然嗅觉功能总体上有所改善,但研究的干预措施在这个马来西亚队列中没有提供显著的附加益处.

关键词:

在COVID-19中,有很多人.莫梅索尼鼻喷雾剂莫梅索尼鼻喷雾嗅觉的康复嗅觉的康复嗅觉训练是通过嗅觉训练进行的.持续的嗅觉功能障碍持续的嗅觉功能障碍这是COVID-19后的并发症.气味识别测试气味识别测试

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