印度肝细胞癌的系统治疗方法
Vinay Jahagirdar1, Kaanthi Rama2, Mohammed F Habeeb3
1Department of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.
Journal of clinical and experimental hepatology
|July 8, 2024
概括
印度的肝细胞癌 (HCC) 正从病毒性转变为生活方式原因. 像TKIs和免疫疗法这样的系统疗法可以改善生存率,但晚期诊断和访问挑战仍然是HCC管理的关键问题.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 肝细胞癌 (HCC) 是印度癌症死亡的主要原因.
- 病因学正在从病毒性肝炎转向生活方式因素.
- 印度的流行病学趋势和系统疗法格局需要更新分析.
研究的目的:
- 审查印度HCC的流行病学趋势.
- 分析印度背景下HCC系统治疗的现状.
- 讨论印度HCC管理的挑战和未来战略.
主要方法:
- 综合文献综述,包括全球癌症观测中心和印度医学研究理事会的数据.
- 对全身疗法的临床试验进行批判性分析.
- 系统性治疗疗效的评估,机制和适应印度医疗保健框架.
主要成果:
- 氨酸激酶抑制剂 (sorafenib,lenvatinib) 和免疫检查点抑制剂是关键的全身疗法.
- 伦瓦替尼布提供了一个具有成本效益的选择;阿特佐利祖马布加贝瓦齐祖马布显示出优越的生存结果.
- 确定临床试验的临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床临床
结论:
- 系统治疗的进步正在扩大印度HCC的治疗选择.
- 晚期诊断和有限的医疗保健可用性阻碍了有效的管理,往往导致息治疗.
- 专注于早期检测,意识,查和解决基础设施差异的综合方法对于改善印度的HCC护理至关重要.
相关概念视频
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:27Tumor Immunotherapy
509
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
509
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K