持续释放的布里莫尼丁从结膜囊插入,以降低眼内压力为绿眼治疗
Zhutian Zhang1, Qian Ma2, Zhaoxing Dai3
1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Shanghai Medical College, Fudan University; NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China.
Expert opinion on drug delivery
|July 8, 2024
概括
一种新型的含有布里莫尼丁的膠插件,可持續降低眼內壓力 (IOP) 來治療青光腫. 这种植入物提供了一个有希望的,非侵入性的替代每日眼滴,改善患者的遵守和治疗结果.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 玻璃眼是全球不可逆转的失明的主要原因.
- 目前的治疗主要涉及降低眼内压力 (IOP),使用每日滴眼液.
- 眼滴的局限性包括药物持续时间短,生物可用性差,影响治疗疗效和患者坚持治疗.
研究的目的:
- 开发和评估一种新型的布里莫尼丁加载的膠插件 (BRI@SR@PT),用于持续降低眼内压力 (IOP).
- 评估BRI@SR@PT.的物理特性,体外特征和体内性能.
- 为了比较BRI@SR@PT与传统的布里莫尼丁眼液的疗效和安全性.
主要方法:
- 准备BRI@SR@PT通过布里莫尼丁加载到表面修改的环中,然后涂上聚多巴胺/热塑性聚氨涂层.
- 评估物理性质,体外细胞相容性和药物释放动力学.
- 在体内评估药物释放,IOP降低功效,并在结膜袋管理后子眼中的生物安全性.
主要成果:
- 该BRI@SR@PT显示出出色的热稳定性和弹性.
- 从插入物中持续释放布里莫尼丁被观察到28天,体外毒性最小.
- 在体内研究表明,在子眼中21天有效降低IOP,具有良好的生物安全性,性能优于常规眼滴.
结论:
- 结膜囊插入 (BRI@SR@PT) 作为一个有前途的药物输送平台.
- 本插件提供了一种持续的,非侵入性的内血压降低治疗眼睛高血压和玻璃眼.
- BRI@SR@PT可以通过消除频繁使用眼滴的必要性来提高患者的遵守性.
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