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放射性酸微球赋能可持续的实地瘤疫苗接种

Pei Xu¹, Yuan Gu¹, Chenze Li¹

¹State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.

|July 8, 2024

概括

这项研究引入了一种新的现场疫苗接种 (ISV) 方法,使用标记为Lu的微球持续释放瘤抗原. 这种方法有效地产生强大的抗瘤免疫力,并防止小鼠的瘤复发.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
辐射疗法辐射疗法

背景情况:

瘤本位疫苗接种 (ISV) 在癌症治疗的临床试验中显示出有前途.
目前的ISV方法在实现持续免疫反应方面面临挑战.
局部放射治疗和内辅助剂注射是ISV的关键组成部分.

研究的目的:

开发一种赋权和可持续的ISV方法,用于增强抗瘤治疗.
为了利用标记为Lu的配合的性半孔酸 (Lu/Mn-HAP) 微球进行持续的抗原递送.
研究新型ISV策略的免疫反应和治疗疗效.

主要方法:

制造用于ISV.177的Lu标记的Mn-HAP微球.
用于持续的瘤抗原释放和辅助作用的微球.
评估免疫细胞激活 (树突细胞,M1巨细胞) 和CD8+T细胞反应.
在小鼠模型中对初级和远程瘤的抗瘤作用的评估.

主要成果:

这177个Lu/Mn-HAP微球促进了持续的瘤抗原利用.
这导致了树突细胞的增强激活和M1巨细胞的两极分化.
产生了强大的CD8+T细胞反应,改善了内部放射治疗的疗效.
在所有接受治疗的小鼠中实现了完整的瘤缓解,并且建立了预防复发的免疫记忆.

结论:

开发的基于Lu/Mn-HAP微球的177ISV是一种安全和通用的战略.
这种方法诱导了强烈的,瘤特异的和可持续的免疫反应.
它为有效的抗瘤治疗和长期预防瘤复发提供了有希望的方法.

关键词:

抗瘤免疫力免疫力免疫性细胞死亡免疫性细胞死亡在现场接种疫苗.放射性微球是放射性的微球.可持续的抗原利用.

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