丹麦血清阳性和血清阴性类风湿性关节炎的发病率:全国性基于人口的全国性研究
B G Soussi1,2, R L Cordtz1, K Duch1
1Center of Rheumatic Research Aalborg, Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark.
Scandinavian journal of rheumatology
|July 8, 2024
概括
血清阳性类风湿性关节炎 (RA) 的发生率正在增加,而血清阴性RA的发生率正在下降. 这种转变可能是由于随着时间的推移增加了自身抗体测试和诊断实践.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 风湿性关节炎 (RA) 诊断依赖于血清学标志物,但血清阳性与血清阴性RA发病率的趋势尚未完全理解.
- 了解这些趋势对于准确的疾病负担评估和资源分配至关重要.
研究的目的:
- 调查和比较丹麦血清阳性和血清阴性类风湿性关节炎 (RA) 的发病率 (IRs).
- 使用多种数据源分析RA血清学亚型的时间趋势.
主要方法:
- 一项全国性的基于人口的队列研究,利用丹麦的医疗保健和临床质量登记册从2000年到2018年.
- 使用来自多个来源的抗循环素和免疫球蛋白M类风湿因子数据来确定血清阳性.
- 每10万人年 (PY) 的年均年龄和性别标准化IR计算.
主要成果:
- 在血清阳性RA的IR中观察到时间上升的趋势,在血清阴性RA中观察到下降的趋势.
- 从2009年开始,血清阳性RA IR超过了血清阴性RA IR,差距越来越大.
- 在2018年,血清阳性RA的IR大约是血清阴性RA的两倍 (19.0对比9.0每10万PY).
- 在研究期间,自身抗体检测水平显著增加.
结论:
- 随着时间的推移,血清阳性RA的IR已经上升,而血清阴性RA的IR已经下降.
- 这些时间转移可能反映了RA血清学亚型的实际变化,增加了自身抗体测试,或不断变化的注册实践.
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