在有机胃肠道疾病中与肠-大脑相互作用 (DGBI) 障碍相容的症状概况:基于全球人口的研究
Tom van Gils1, Jóhann P Hreinsson1, Hans Törnblom1
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
United European gastroenterology journal
|July 8, 2024
概括
肠-大脑相互作用障碍 (DGBI) 症状在有机胃肠道疾病或糖尿病患者中更为常见. 这些情况往往并存,应在患者管理中考虑.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 内部医学 内部医学
背景情况:
- 有机胃肠道 (GI) 疾病和糖尿病 (DM) 可能与肠-大脑相互作用 (DGBI) 障碍一起发生.
- 了解这些患者群体中DGBI的患病率对于有效管理至关重要.
- 以前的研究已经表明了潜在的联系,但全球流行数据有限.
研究的目的:
- 为了比较DGBI兼容症状的全球患病率,在有或没有自我报告的有机肠道疾病或DM的成年人中.
- 量化特定的有机GI疾病和DGBI症状概况之间的关联.
- 调查DM和DGBI症状概况之间的关联强度.
主要方法:
- 在26个国家 (n=54,127) 进行了一项大规模的基于人口的互联网调查,称为罗马基金会全球流行病学研究.
- 参与者报告了医生诊断的有机胃肠道疾病 (例如IBD,腹腔炎,胃肠癌) 或DM.
- 使用罗马IV诊断标准评估了DGBI兼容的症状概况,使用混合后勤回归进行统计分析.
主要成果:
- 有机肠道疾病的个体显示,DGBI兼容的症状概率显著更高 (ORs从肠道癌的1.64到IBD的3.22).
- 糖尿病也与DGBI症状的几率增加有关 (OR 1.26),尽管不如大多数有机肠道疾病那么强烈.
- 观察到特定疾病,如便失禁和腹腔疾病 (OR 6.94),以及炎症性肠病 (IBD) 和肠道DGBI之间存在强烈的关联.
- 即使调整了混因素,这些联系仍然存在.
结论:
- 与一般人群相比,在自我报告的有机肠道疾病和DM患者中,DGBI兼容的症状概况更为普遍.
- DGBI与有机胃肠道疾病和DM的同时发生是一个重要的发现,需要得到临床关注.
- 医疗保健提供者在治疗患有这些疾病的患者时,应考虑并发性DGBI的潜在存在.
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