Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Working Memory01:24

Working Memory

151
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
151

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Aberrant Brain Topological Properties in Early-Onset and Adult-Onset Schizophrenia: Evidence from First-Episode Drug-Naïve and Medicated Groups.

Journal of the American Academy of Child and Adolescent Psychiatry·2026
Same author

Uncovering Shared and Distinct Brain Connectome Dynamics in Working Memory Tasks Between Bipolar and Unipolar Depression.

Bipolar disorders·2026
Same author

A hierarchical multi-scale framework for schizophrenia: integrating symptom networks, functional circuits, and molecular pathways.

Molecular psychiatry·2026
Same author

Age of onset: static and dynamic brain regional activity in first-episode drug-naïve schizophrenia.

European child & adolescent psychiatry·2026
Same author

Brain state dynamics and working memory in patients with major depressive disorder and bipolar disorder.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.

Psychological medicine·2026

相关实验视频

Updated: Jun 21, 2025

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
16:08

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

16.1K

在工作记忆任务期间,严重抑郁症中异常的大脑动态.

Fuping Sun1, Zhening Liu1, Jun Yang1

  • 1Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.

European archives of psychiatry and clinical neuroscience
|July 8, 2024
PubMed
概括

大型抑郁症 (MDD) 患者在工作记忆 (WM) 任务中表现出大脑不稳定的增加. 这种增加的大脑活动的变化,特别是在关键区域,与较差的WM性能相关,这表明稳定性增强可能有助于恢复.

关键词:
默认模式的网络模式是默认模式.抑郁症 抑郁症 抑郁症动态的中心性程度.边界对称网络的前沿.在海马体内,海马体在N-back的背部.

更多相关视频

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.1K
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

10.5K

相关实验视频

Last Updated: Jun 21, 2025

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
16:08

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

16.1K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.1K
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

10.5K

科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 认知科学 认知科学

背景情况:

  • 工作记忆 (WM) 缺陷是主要抑郁障碍 (MDD) 的关键内分类型候选者.
  • 在MDD中潜在的WM缺陷的精确时空大脑动态仍然不太了解.

研究的目的:

  • 通过使用动态度中心性 (dDC) 来研究MDD中WM缺陷的全脑时空概况.
  • 在不同的WM负载期间探索dDC时间变化和元稳定大脑状态的群体差异.

主要方法:

  • 从40名MDD患者和40名对照患者的fMRI数据,在2-back和0-back任务中.
  • 对dDC时间变化和元稳定状态的分析.
  • 皮尔森的相关性将大脑动态与临床症状和WM表现联系起来.

主要成果:

  • 患有MDD的患者在包括中额头,下额头轨道部分 (IFGorb),海马和中额头在内的区域表现出显著增加的dDC变异性.
  • 在海马和IFGorb中增加的dDC可变性与更差的WM性能相关.
  • 在超稳定的大脑状态中没有发现任何显著的群体差异.

结论:

  • MDD的特征是与WM相关的大脑不稳定性增加,由增加的dDC可变性表明.
  • 像海马体和IFGorb这样的特定区域的大脑活动的不稳定性与MDD中WM功能受损有关.
  • 增强大脑活动稳定的策略可能会改善MDD患者的WM表现.