早期和晚期评估使用Intravoxel不连贯运动 (IVIM) 和扩散权重成像 (DWI) 的代移植功能障碍:一项前性研究
Mostafa El-Ksas1, Dina El-Metwally2, Dalia Fahmy2
1Radiology Department, Urology and Nephrology Center, Mansoura University, El Gomhoureya St, Mansoura, Egypt.
Abdominal radiology (New York)
|July 8, 2024
概括
内素不连贯运动 (IVIM) 和明显扩散系数 (ADC) 值是评估移植功能的重要生物标志物. 皮质ADC和伪扩散 (D*) 显示出高性能,D* 在晚期移植评估中优越.
科学领域:
- 放射学 放射学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學.
- 医疗成像医学成像
背景情况:
- 在移植后,对脏全移植功能进行监测至关重要.
- 像IVIM和ADC这样的定量扩散MRI技术提供了非侵入性评估潜力.
- 早期发现移植病理对于患者的治疗结果至关重要.
研究的目的:
- 在早期和晚期移植阶段评估合移植功能的过程中,评估Intravoxel Incoherent Motion (IVIM) 和单指数ADC.
- 预测这些参数在分辨移植病理中的有效性.
主要方法:
- 一项前性研究,涉及105名移植接受者.
- 在3T扫描仪上获得的定量扩散和 perfusion MRI 序列.
- 计算ADC和IVIM参数,然后对eGFR进行相关性和回归分析,移植期和病理.
主要成果:
- 在整体和皮质ADC/IVIM参数与估计的淋巴细胞过率 (eGFR) 之间发现了显著的正相关性.
- 皮层伪扩散 (D*) 和皮层ADC形成了对eGFR组 (AUC 96%) 的重要预测模型.
- 在晚期移植评估中,D*的相关性高于ADC.
结论:
- IVIM和ADC值是代移植功能的重要生物标志物.
- 皮层ADC和D*表现出高性能,在影响eGFR之前检测出微妙的损伤.
- 在晚期移植评估中,D*优于ADC.
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