相关实验视频

Updated: Jun 21, 2025

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

基于胺基酸盐的新型技术-99m标记双价PSMA准探针用于诊断前列腺癌

Yoichi Shimizu^1,2, Masato Ando³, Hiroyuki Watanabe³

¹Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29, Yoshida Shimoadachi-Cho, Sakyo-Ku, Kyoto, 606-8501, Japan. yoichis@kuhp.kyoto-u.ac.jp.

Annals of nuclear medicine

|July 8, 2024

概括

这项研究开发了一种新型的技术-99m标记探头,[99mTc]Tc-(Ham-SCUE) 2,用于成像前列腺癌. 探测器显示PSMA表达细胞和瘤的吸收率很高,表明其对SPECT成像的潜力.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

前列腺特异性膜抗原 (PSMA) 是前列腺癌的关键生物标志物.
苏奇尼米迪尔-氨酸-氨酸酸盐 (SCUE) 部分对PSMA具有很高的亲和力.
之前的研究确定了基于SCUE的化合物的潜力.

研究的目的:

开发和评估一种标有99m技术的新型PSMA准探头,[99mTc]Tc-(Ham-SCUE) 2.
评估其作为SPECT成像剂的疗效,用于诊断表达PSMA的前列腺癌.

主要方法:

汉姆-SCUE的合成和随后用99m技术进行放射性标记,以获得[99mTc]Tc-{汉姆-SCUE) 2.
使用LNCaP (高PSMA) 和PC3 (低PSMA) 细胞进行体外评估,包括使用2-PMPA进行吸收和阻断研究.
在双重异种移植的小鼠体内生物分布研究,包括阻断实验.

主要成果:

[99mTc]Tc-(Ham-SCUE) 2的制备具有高放射性化学产量 (>95%的纯度).
与PC3细胞相比,在LNCaP细胞中观察到显著更高的细胞吸收,PSMA抑制剂研究证实了这一点.
在体内研究表明,在LNCaP瘤中,PC3瘤的积累优于LNCaP瘤,2-PMPA显著抑制.

结论:

[99mTc]Tc-(Ham-SCUE) 2显示出对表达PSMA的细胞和瘤的特定向.
该探针显示出作为前列腺癌诊断SPECT成像剂的潜力.

关键词:

标有99mTc的双价联体探针.胺胺是一种胺.在PSMA上,PSMA可以在PSMA上进行交易.技术-99m是什么意思

更多相关视频

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Published on: February 4, 2017

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

相关概念视频

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...