父母炎症性肠病与儿童自闭症:全面的审查和元分析
Xingmu Wang1, Chenfei Qian2, Huanying Yao3
1Clinical Laboratory Center, Shaoxing People's Hospital, Shaoxing, Zhejiang, P.R. China.
Journal of autism and developmental disorders
|July 8, 2024
概括
父母的炎症性肠病 (IBD) 与儿童患自闭症谱系障碍 (ASD) 的风险增加没有显著联系. 这次元分析没有发现确的证据支持IBD在父母和ASD在后代之间的联系.
科学领域:
- 胃肠病学和神经病学
- 儿科健康 儿科健康
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 与神经系统疾病的风险增加有关,包括自闭症谱系障碍 (ASD).
- 现有的证据将父母的IBD与后代的ASD联系起来是不确定的,需要进一步调查.
研究的目的:
- 进行元分析和综合审查,以确定父母IBD和儿童ASD之间的关联.
- 阐明母亲或父亲的IBD与他们后代的ASD发病率之间的潜在联系.
主要方法:
- 从1960年到2022年12月,在多个数据库 (Cochrane,知识网络,Embase,CINAHL,PubMed,PsycINFO) 进行系统的文献搜索.
- 六项涉及3,200,199名参与者的研究 (两个病例控制,四个队列) 的元分析,使用随机效应模型计算聚合相对风险 (RRs) 和95%置信区间 (CI).
- 包括预测间隔 (PI) 来评估潜在真实效应的范围.
主要成果:
- 父母患有IBD后代的ASD的汇总RR为1.15 (95% CI,0.92至1.45),表明没有统计学上显著的关联 (P=0.226).
- 观察到高异质性 (I2=81.4%,P=0.003),预测间隔为0.53-2.62.
- 基于IBD类型和性别的子组分析没有产生显著的结果.
结论:
- 这一元分析不支持父母IBD与儿童ASD风险增加之间的联系.
- 需要进一步研究更大的样本大小和强大的研究设计来证实这些发现并探索潜在的机制.
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