非辅助的双对应呼吸道同胞性病毒疫苗接种和围产期结局
Moeun Son1, Laura E Riley1, Anna P Staniczenko1
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York.
JAMA network open
|July 8, 2024
概括
针对孕妇的新型呼吸道同胞性病毒 (RSV) 预注射F (RSVpreF) 疫苗没有显示过早分娩或其他不良周产期结局的风险增加. 需要进一步的研究来调查与妊娠高血压疾病的潜在联系.
科学领域:
- 产科和妇科 产科和妇科
- 疫苗学 疫苗学 疫苗学
- 新生儿健康 新生儿健康
背景情况:
- 一种新的双价呼吸道同胞性病毒 (RSV) 前输F (RSVpreF) 蛋白子单元疫苗已被批准用于孕妇.
- 关于怀孕期间这种疫苗的安全性和有效性的临床数据有限.
- 建议在怀孕32 0/7至36 6/7周之间接种疫苗.
研究的目的:
- 评估产前RSV疫苗接种和围产期结局之间的关联.
- 评估RSVpreF疫苗在孕妇及其新生儿中的安全性.
- 为了确定与母体RSV疫苗接种相关的任何潜在风险或益处.
主要方法:
- 在纽约两家医院进行了回顾性观察性队列研究.
- 包括那些在怀孕32周或更晚时分娩单子妊娠的患者.
- 利用电子健康记录来识别疫苗接种状态和跟踪围产期结果.
主要成果:
- 在2973名参与者中,34.5%接种了RSVpreF疫苗.
- 产前疫苗接种与早产风险增加无关 (经调整的OR,0.87;95% CI,0.62-1.20).
- 大多数新生儿结局没有发现显著差异,但在一个模型中 (HR, 1.43; 95% CI, 1.16-1.77) 发现妊娠高血压疾病 (HDP) 的风险增加.
结论:
- 在这个群体中,RSVpreF疫苗在早产和大多数围产期结局方面似乎是安全的.
- 数据支持产前RSVpreF疫苗接种的安全性.
- 需要进一步的研究,以探索与妊娠高血压疾病的潜在关联.
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