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在性结肠炎中乌帕达西提尼布和托法西提尼布的比较有效性:美国倾向匹配的队列研究
Gursimran S Kochhar1, Himsikhar Khataniar2, Vipul Jairath3
1Division of Gastroenterology, Hepatology and Nutrition, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
与tofacitinib相比,upadacitinib在12个月后在性结肠炎 (UC) 患者中显示出改善的疾病结果. 这项现实研究发现,使用upadacitinib,切除肠道的风险较低.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的现实世界数据存在,比较upadacitinib和tofacitinib治疗性结肠炎 (UC).
- 了解比较疗效对于优化UC治疗策略至关重要.
研究的目的:
- 在患有UC的患者中,比较upadacitinib与tofacitinib的实际有效性.
- 评估在6个月和12个月内需要静脉注射类固醇和/或切除术的住院风险.
主要方法:
- 使用多机构TrinetX数据库进行的回顾性队列研究.
- 对人口统计,并发症和先前治疗进行一对一的倾向性得分匹配.
- 主要结局:综合性静脉注射类固醇住院治疗和/或在6个月和12个月后的切除术.
主要成果:
- 在六个月后的综合结果中,upadacitinib和tofacitinib之间没有显著的差异.
- 在12个月后,upadacitinib显示复合结果的风险明显降低 (aOR 0.63).
- 观察到12个月后使用upadacitinib的小肠切除术风险较低 (aOR 0.46).
结论:
- 与UC患者的tofacitinib相比,upadacitinib与12个月后改善的疾病特异性结果有关.
- 现实世界的数据支持upadacitinib作为长期UC管理的潜在更有效选择.
- 进一步的研究可能会探索从每种疗法中受益最多的特定患者子组.
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