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治疗家族高胆固醇血症的性别差异:一个元分析

Iulia Iatan¹, Leo E Akioyamen², Isabelle Ruel³

¹Department of Medicine, Centre for Heart Lung Innovation, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada.

European heart journal

|July 8, 2024

概括

患有家族性高胆固醇血症 (FH) 的女性接受的治疗不那么密集,并且不太可能达到LDL胆固醇目标. 在FH护理中这种性别偏见是预防心血管疾病的重要,但可以克服的障碍.

科学领域:

心脏病学心脏病学
遗传学是一个遗传学.
公共卫生公共卫生

背景情况:

家族性高胆固醇血症 (FH) 是一种常见的遗传疾病,导致高的LDL胆固醇和早期心血管疾病.
在全球范围内,在FH诊断,治疗和结果方面存在性别差异.
了解这些差异对于改善患者护理至关重要.

研究的目的:

系统地审查和分析治疗的性别相关差异和成年人患有FH的脂质标的实现.
为了确定护理女性FH的障碍.

主要方法:

对多个数据库 (MEDLINE,Embase,Cochrane,PubMed,Scopus,PsycInfo) 和灰色文献进行了全面的系统审查.
纳入标准侧重于报告成人FH治疗中性别差异的研究.
数据综合包括干预试验和观察性研究的元分析.

主要成果:

对16项干预试验 (1840名参与者) 的分析表明,对降脂疗法的反应没有性别差异.
对25项观察性研究 (129441名参与者) 的分析显示,女性接受治疗 (OR .74) 和达到LDL-C目标 (OR .85) 的可能性较低.
女性治疗的LDL-C水平较高,而男性患主要心血管不良事件的风险较高.

结论:

患有FH的女性接受治疗不足,并且不太可能达到指南推的LDL-C目标.
在FH管理中这种性别偏见是最大限度地降低心血管风险的重要障碍.
解决这种差异对于公平有效的FH护理至关重要.

关键词:

动脉样硬化心血管疾病.家庭性高胆固醇血症 (FAMI) 是一种家族性高胆固醇血症.雌性雌性雌性降脂治疗治疗降脂治疗性差异性差异性差异性差异性差异性差异性差异性系统性审查系统性审查

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