根据个人的风险概况进行胃癌查的个性化起始年龄:基于人口的前性研究
Siyi He1, Zhiyi Zhang2, Guohui Song3
1Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Journal of the National Cancer Institute
|July 8, 2024
概括
胃癌查年龄可以根据个人风险因素进行个性化. 高风险人群应该更早开始查,而低风险人群可以推迟查.
科学领域:
- 在瘤学瘤学.
- 预防医学 预防医学
- 流行病学 流行病学
背景情况:
- 目前的胃癌查指南缺乏统一的开始年龄建议和个性化的标准.
- 胃癌查需要风险分层的方法.
- 制定个性化查策略对于有效的早期检测至关重要.
研究的目的:
- 确定中国胃癌查的风险分层起始年龄.
- 为个性化胃癌查年龄应用程序开发一个在线计算器.
- 建立基于风险概况的个性化查标准.
主要方法:
- 这是一项多中心,基于人口的前性研究,涉及59,771名年龄在40-69岁之间的参与者.
- 倾向性得分匹配被用来评估按年龄组的查有效性.
- 个人风险得分是使用8个已知风险因素计算的,并按量级分类.
主要成果:
- 查降低了45岁及以上,50-59岁的个体的全因和胃癌特异性死亡率.
- 胃癌查的平均人口 (参考) 起始年龄被确定为50岁.
- 风险分层的开始年龄为低风险的58岁,中风险的50岁,高风险的46岁.
结论:
- 高危人群应比普通人群 (50岁) 早3-5年开始胃癌查.
- 低风险的人可以安全地推迟他们的胃癌查.
- 在线个性化起始年龄计算器可用于促进风险适应的胃癌查.
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