本质抗微生物耐药性:分子生物材料用于对抗微生物生物膜和细菌持久性
Swagatam Barman1, Leman Buzoglu Kurnaz2, Ryan Leighton3
1Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, 29208, United States; Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, 29208, United States.
Biomaterials
|July 8, 2024
概括
抗菌素耐药性 (AMR) 和持续性感染构成了全球健康威胁. 本综述探讨了旨在克服耐药性,生物膜和持久细胞的新型分子生物材料和治疗方法,为治疗慢性感染提供了新的希望.
科学领域:
- 生物材料科学 生物材料科学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益严重的全球卫生危机,由生物膜和耐常抗生素的细菌持续细胞加剧.
- 目前的抗生素管道不足以应对日益严重的多药耐药性 (MDR) 感染的威胁.
- 生物膜和持久细胞提供了增强的微生物生存策略,使感染治疗复杂化.
研究的目的:
- 审查分子生物材料和治疗药物的进展,以对抗获得性和内在性AMR.
- 在AMR的背景下阐明生物膜和持久细胞的微生物学.
- 为未来的生物材料设计提供视角,以克服AMR和治疗慢性MDR感染.
主要方法:
- 审查关于AMR,生物膜,持久细胞和新型治疗策略的现有文献.
- 对各种生物材料方法对抗内在AMR进行分类和分析.
- 阐明不同类别的生物材料的结构-活性关系.
主要成果:
- 讨论半合成抗生素,抗微生物模仿生物材料,协同辅助剂,纳米疗法,氧化释放剂,抗微生物水凝和涂料.
- 突出这些生物材料在解决获得性和内在性AMR方面的潜力.
- 强调了解结构-活动关系对于有效的生物材料设计的重要性.
结论:
- 分子生物材料为打击AMR,生物膜和持久细胞提供了有希望的途径.
- 对生物材料设计进行进一步的研究,重点关注结构-活动关系,对于开发有效的治疗方法至关重要.
- 新型疗法对于克服常规抗生素在治疗慢性和MDR感染方面的局限性至关重要.
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