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Updated: Jun 21, 2025

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在患有胃食道癌的患者中,化疗诱导的外周神经病变
Merel J M van Velzen1,2, Marieke Pape1,2,3, Mirjam A G Sprangers2,4
1Department of Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
概括
化疗诱导的周围神经病变 (CIPN) 在胃食道癌 (GEC) 患者中很常见,显著影响生活质量. 由于CIPN的高患病率和与健康相关的生活质量降低的关联,早期识别CIPN至关重要.
科学领域:
- 在瘤学瘤学.
- 临床药理学 临床药理学
- 患者报告的结果
背景情况:
- 胃食道癌 (GEC) 治疗,包括化疗,经常导致神经毒性.
- 化疗诱导的周围神经病变 (CIPN) 是一种显著的不良影响,降低了GEC患者的与健康相关的生活质量 (HRQoL).
研究的目的:
- 调查正在接受GEC治疗的患者中CIPN的发生率和严重程度.
- 在这个患者群体中分析CIPN和HRQoL之间的关联.
主要方法:
- 从荷兰癌症登记处确定了一组2,135名接受化学辐射疗法或化疗的GEC患者.
- 患者报告的结果,包括CIPN (EORTC QLQ-CIPN20) 和HRQoL (EORTC QLQ-C30),在24个月内被收集.
- 使用线性混合效应模型和斯皮尔曼相关性来评估CIPN的发展及其与HRQoL的关系.
主要成果:
- 在所有GEC治疗组 (化疗放射治疗,治愈化疗,缓解化疗) 中,CIPN的发生率和严重程度在治疗期间显著增加.
- 化疗放射治疗患者的CIPN得分在治疗后继续上升,而化疗组的得分下降,但仍然高于基线.
- 在所有治疗组中,在CIPN和HRQoL之间观察到显著的负相关性,随着时间的推移,强度和意义各不相同.
结论:
- 鉴于GEC的预后不佳,像CIPN这样的治疗相关毒性管理是必不可少的.
- CIPN对HRQoL的高患病率和有害影响强调了其在GEC患者的早期检测和管理的重要性.
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