基于多层同轴亚格的电生物复合材料的制造和表征,用于皮肤贴片的新型替代品
Kalpana Rathore1, Indrajeet Singh2, Kantesh Balani2
1Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, India; Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara, Punjab, India.
International journal of biological macromolecules
|July 8, 2024
概括
这项研究开发了新型的以基为基础的纳米纤维,用于穿皮贴片. 由此产生的双层敷料对有效的药物输送和生物医学应用具有前景.
科学领域:
- 生物材料工程 生物材料工程
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 通过皮肤贴片需要先进的材料来有效地输送药物.
- 基于阿加的纳米纤维为创建复杂的生物医学带提供了潜力.
- 开发不对称的双层结构是控制释放应用的关键.
研究的目的:
- 为了制造和表征新型的阿加基纳米纤维用于不对称的双层敷料.
- 为了优化基于阿加的纳米纤维生产的电旋参数.
- 评估这些敷料作为药物输送的透皮贴片的潜力.
主要方法:
- 基于阿加的纳米纤维和同轴纳米纤维 (聚乙烯醇与塞法莱克辛水合物核心,阿加-多聚烯酸罩) 的电.
- 优化制造参数,包括料速率,采集器距离,电压和采集器速度.
- 使用扫描电子显微镜 (SEM) 和传输电子显微镜 (TEM) 的形态分析.
- 机械性能,胀,湿透性和湿度传递率的表征.
主要成果:
- 优化的电参数产生了均的基于的纳米纤维.
- 不对称的双层结构成功地用agar-PCL和同轴PVA/agar-PCL层制造.
- 纳米纤维地毯显示出显著的胀,增强的湿透性,以及高的湿度传递率.
- 开发的包裹表现出抗菌活性,血红相容性和细胞相容性.
结论:
- 基于的新型纳米纤维已成功制造成不对称的双层敷料.
- 包裹显示出优良的物理性能,适合通过皮肤贴片的应用.
- 开发的材料具有生物相容性和抗微生物特性,这表明先进的药物输送系统具有很大的潜力.
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