Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

GPCR Desensitization01:12

GPCR Desensitization

5.9K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
5.9K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

611
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
611

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Xiongzhi Qufeng Zhitong Granule alleviates nitroglycerin-induced migraine-like nociception and central neuroinflammation by regulating the HMGB1 / TRPV1 / MAPK signaling axis.

Journal of ethnopharmacology·2026
Same author

The impact of face-to-face social exclusion on university students' interpersonal cooperation behavior: a hyperscanning study based on fNIRS.

Frontiers in neuroscience·2026
Same author

Spatiotemporal evolution and drivers of carbon stock in arid oases: Multi-source assessment and scenario prediction in Wei-Ku oasis, China.

iScience·2026
Same author

Uniaxial spin texture in a superconducting electron gas revealed by exchange interactions.

Science advances·2026
Same author

A single-component photocurable chitosan hydrogel mitigates inflammation and promotes angiogenesis and neurogenesis for diabetic wound healing.

Biomaterials·2026
Same author

Association Between Autism-Related Symptoms and Mealtime Behavior Problems in Children With Autism Spectrum Disorders.

Journal of autism and developmental disorders·2026
Same journal

An advanced hydrological approach for the characterization of the Water Scarcity Footprint at the sub-basin level.

The Science of the total environment·2026
Same journal

Irrigation management and groundwater recharge in Mediterranean intermontane basins: a multi-method evaluation of agricultural controls and interbasin variability.

The Science of the total environment·2026
Same journal

Environmental variables improve remote sensing-based water table monitoring in peatlands.

The Science of the total environment·2026
Same journal

Climate extremes, WASH deficits, and infectious diseases in the Brazilian Amazon: Insights from explainable machine learning (2010-2022).

The Science of the total environment·2026
Same journal

Life cycle assessment as a tool to improve the environmental sustainability of urban forest management - An Italian case study.

The Science of the total environment·2026
Same journal

Retraction notice to "Fate, bioaccumulation and toxicity of engineered nanomaterials in plants: Current challenges and future prospects" [Sci. Total Environ. 811 (2022) 152249].

The Science of the total environment·2026
查看所有相关文章

相关实验视频

Updated: Jun 21, 2025

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell
08:11

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell

Published on: August 14, 2021

4.5K

聚乙烯微塑料通过GPX1触发丸激素的下降.

Jiayuan Qu1, Liling Wu1, Li Mou1

  • 1NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 401120, PR China.

The Science of the total environment
|July 8, 2024
PubMed
概括
此摘要是机器生成的。

聚烯微塑料 (PS-MPs) 通过破坏的合成来损害男性的生殖能力. 这些微塑料在丸中积聚,降低莱迪格细胞活力,并触发氧化和内质网膜应激,导致丸水平降低.

关键词:
在GPX1中,GpX1是GpX1.在PERK-EIF2α-ATF4-CHOP路径中.聚乙烯微塑料的微塑料.的下降 的下降 的下降在Ubiquitination中使用.

更多相关视频

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:27

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

715

相关实验视频

Last Updated: Jun 21, 2025

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell
08:11

Ecotoxicological Effects of Microplastics on Bird Embryo Development by Hatching without Eggshell

Published on: August 14, 2021

4.5K
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:27

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

715

科学领域:

  • 环境科学 环境科学
  • 毒理学 毒理学 毒理学
  • 生殖生物学 生殖生物学

背景情况:

  • 聚烯微塑料 (PS-MPs) 是新兴的环境污染物.
  • 怀疑PS-MPs是具有抗雄激素特性的内分泌干扰剂.
  • 对男性生殖功能的不良影响越来越令人担忧.

研究的目的:

  • 调查PS-MPs对的合成和男性生殖的不良影响.
  • 阐明PS-MP诱导的生殖损伤的潜在机制.
  • 评估氧化和内质网膜应激通路的作用.

主要方法:

  • 暴露BALB/c小鼠和莱迪格细胞50微米PS-MPs.
  • 丸组织的组织形态学和超结构分析.
  • 测量血清荷尔蒙水平 (GnRH,FSH,LH,丸激素).
  • 研究分子通路,包括无处不在,miR-425-3p,GPX1和ER压力 (PERK-EIF2α-ATF4-CHOP).

主要成果:

  • 在小鼠丸和莱迪格细胞中积累了PS-MPs,造成损伤.
  • 观察到莱迪格细胞活力的降低和血清激素水平的抑制.
  • 通过GPX1抑制,PS-MPs诱导了氧化应激.
  • 细胞内膜网膜应激通路 (PERK-EIF2α-ATF4-CHOP) 被激活.
  • CHOP提高了SRD5A2的调节,加速了丸激素的新陈代谢.
  • 与下丘脑-垂体-丸 (HPT) 轴的干扰注意到.

结论:

  • PS-MPs表现出抗雄激素特征并损害男性生殖功能.
  • 在PS-MP诱导的丸激素下降中,GPX1起着至关重要的作用.
  • 通过多个分子途径,PS-MPs会破坏丸激素的平衡.