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低剂量辐射暴露后的修复作用:通过减少NETs释放来抑制动脉样硬化
Shugen Qu1, Xu Qiu2, Jiao Liu2
1School of Public Health, Wenzhou Medical University, Wenzhou 325035, China; Key Laboratory of Watershed Science and Health in Zhejiang Province, Wenzhou 325035, China; South Zhejiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou 325809, China.
The Science of the total environment
|July 8, 2024
概括
低剂量辐射暴露可能通过影响中性粒细胞和它们释放中性粒细胞外细胞陷 (NETs) 来抑制动脉样硬化. 这项研究探讨了潜在的机制,发现辐射减少了动物模型中的NET和斑块形成.
科学领域:
- 心血管科学 心血管科学
- 辐射生物学 辐射生物学
- 免疫学 免疫学 免疫学
背景情况:
- 低剂量辐射暴露对心血管的影响尚不清楚.
- 调查辐射和动脉样硬化之间的联系对于辐射从业者来说至关重要.
- 动脉样硬化发展涉及复杂的生物途径.
研究的目的:
- 探索将低剂量辐射与动脉样硬化相关联的机制.
- 进行一个多主题的联合综合实验.
- 为了确定辐射损伤和动脉样硬化之间的共享基因和通路.
主要方法:
- 权重基因同表达网络分析 (WGCNA) 和差异分析.
- 对于免疫细胞透分析的CIBERSORT解卷.
- 高脂肪饮食和5Gy马射线照射的动物模型;ELISA用于NETs检测.
主要成果:
- 在辐射损伤和动脉样硬化数据集之间发现的共享基因.
- 中性粒细胞和中性粒细胞外细胞陷 (NETs) 被认为是关键的调解者.
- 低剂量辐射降低了中性粒细胞数量和NETs度,在动物模型中抑制了斑块形成.
结论:
- 长期低剂量的电离辐射暴露会刺激中性粒细胞.
- 中性粒细胞抑制NETs的产生导致动脉样硬化抑制.
- 研究结果表明,低剂量辐射通过中性粒细胞调节对动脉样硬化起着保护作用.
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