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一种双产药纳米凝,结合了Vorinostat和Pyropheophorbide,用于高效的光化学疗法

Weiwei Jiang¹, Yuwei Cheng², Lei Hou²

¹School of Pharmacy, Naval Medical University, Shanghai, China.

International journal of pharmaceutics

|July 8, 2024

概括

这项研究引入了一种新的双原药纳米凝 (PVBN),用于增强癌症光化疗. 纳米凝有效地提供Pyropheophorbide a和Vorinostat,显著抑制瘤生长和转移.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

可吸收的复发和转移仍然是癌症治疗中的重大挑战.
传统的光动力学疗法 (PDT) 药物输送系统面临着脱同步释放和载体不稳定等问题.
需要改进药物输送系统,以提高光化疗的疗效.

研究的目的:

开发一种双原药纳米凝 (PVBN),用于同步和现场药物释放.
研究PVBN对癌细胞和体内瘤模型的治疗作用.
评估PVBN作为增强光化疗策略的潜力.

主要方法:

通过将Pyropheophorbide a (Pyro) 和Vorinostat (SAHA) 与牛血清白蛋白 (BSA) 结合,开发一种双原药纳米凝 (PVBN).
在实验室中评估PVBN对瘤细胞的影响,包括活性氧物种 (ROS) 和乙-H3水平,细胞亡和细胞循环停止.
在体内验证PVBN在患有黑色素瘤的小鼠中的抗瘤功效,评估瘤生长和抑制肺转移.

主要成果:

PVBN促进了溶酶体内同步和自发的药物释放.
治疗PVBN导致ROS和乙-H3水平升高,诱导瘤细胞死亡,亡和细胞循环停止.
在黑色素瘤小鼠模型中,PVBN显著抑制瘤生长并减少肺转移,PDT发挥着主要的协同作用.

结论:

开发的双原药纳米凝 (PVBN) 为克服传统药物输送系统的局限性提供了一个有希望的策略.
通过协同的光化疗,PVBN显示出显著的抗瘤疗效,向瘤生长和转移.
这种新的纳米凝方法有可能提高光化疗在癌症治疗中的临床应用.

关键词:

希斯脱乙酶的使用情况基斯脱乙酶抑制剂基斯脱乙酶抑制剂纳米水凝的水凝光动力学疗法是一种光动力学疗法.氧化酸是一种 pyropheophorbide.

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