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Updated: Jun 21, 2025

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
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考虑到血清和血之间的差异:一种间接方法来推导总蛋白质,白蛋白和血球蛋白的参考间隔

Leah Militello1, Joe M El-Khoury1, Thomas J S Durant2

  • 1Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, United States.

Clinica chimica acta; international journal of clinical chemistry
|July 8, 2024
PubMed
概括

这项研究开发了血清和血蛋白质测量的综合参考间隔 (RI),根据样本类型发现了显著差异. 持续的RI评估对于准确的临床解释至关重要.

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Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
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