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由长时间的过度耐力运动引起的右心室重塑是通过调节Wnt/β-catenin信号在老鼠上升来调节的

Farzaneh Maleki¹, Javad Mehrabani¹

¹Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht 4199843653, Iran.

International journal of cardiology

|July 8, 2024

概括

在大鼠中,强度耐力运动通过Wnt/β-catenin信号传递诱导了右心室 (RV) 重塑和纤维化. 适度强度或训练阻碍了这些不良的心脏变化.

科学领域:

心血管生理学心血管生理学
运动科学运动科学
分子生物学分子生物学

背景情况:

关于耐力运动员的心脏适应是生理还是病理的存在争论.
左心适应得到了很好的研究,但右心 (RV) 改造的理解较少.
这项研究调查了持续高强度运动造成的不良RV重塑.

研究的目的:

开发一种动物模型来研究长时间强烈耐力运动对RV改造的影响.
调查Wnt/β-catenin信号在运动诱导的RV重塑中的作用.
评估运动强度和减速对RV结构和功能的影响.

主要方法:

使用四组雄性Wistar大鼠 (n=8/组):强度炼 (INT),INT随后进行中度炼 (INT+MOD),INT随后进行脱训 (INT+DT),以及久坐 (SED).
运动方案包括每天1小时,每周5天,持续16周.
进行了心声成像,实时PCR,西部涂抹和组织学染色.

主要成果:

与SED和INT+DT组相比,INT大鼠显示出没有扩张功能障碍的集中性缩.
在训练组与SED相比,Wnt1,β-catenin和CyclinD1蛋白质水平显著增加.
INT大鼠表现出增加的原沉积和RV壁厚,与Wnt/β-catenin信号传递有关.

结论:

长期的强化耐力训练与RV重塑和纤维化有关.
似乎Wnt/β-catenin信号通路介导了这些运动引起的心脏变化.
适度强度的运动或阻碍减轻了不良的结构和功能RV变化.

关键词:

进行心脏重塑.长时间的过度耐力运动.右心室的右心室.在Wnt/β-catenin信号传输中.

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