移植前的疫苗接种或感染不会降低所有原性干细胞移植接收者接种疫苗和/或在移植后通过免疫治疗得到保护的COVID-19感染
Valentin Letailleur1, Amandine Le Bourgeois1, Thierry Guillaume1,2
1Hematology Department, Nantes University Hospital, Nantes, France.
Human vaccines & immunotherapeutics
|July 8, 2024
概括
移植前的COVID-19疫苗接种或感染对接受异性干细胞移植 (Allo-SCT) 的患者没有额外的保护. 移植后接种疫苗仍然至关重要,建议在Allo-SCT.后三个月开始接种.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 同源干细胞移植 (Allo-SCT) 是血液病的关键治疗方法.
- 由于COVID-19大流行,需要评估移植周围的疫苗接种和感染影响.
- 了解移植前免疫力对于优化移植后结果至关重要.
研究的目的:
- 评估移植前COVID-19疫苗接种和/或成年Allo-SCT接受者感染的保护作用.
- 确定移植前免疫是否影响移植后疫苗接种和免疫治疗的疗效.
主要方法:
- 对157名接受血液病Allo-SCT治疗的成年患者进行了回顾性研究.
- 在移植之前对COVID-19疫苗接种和感染状况的分析.
- 对移植前免疫状态和干预措施的移植后结果的评估.
主要成果:
- 移植前的COVID-19疫苗接种或感染在接受移植后疫苗,免疫疗法或两者的患者中没有增强保护.
- 该研究没有显示在移植后治疗的背景下,移植前免疫力对COVID-19的额外益处.
结论:
- 移植前的COVID-19免疫力不会为接受移植后疗法的Allo-SCT患者提供额外的保护.
- 艾洛-SCT后的COVID-19疫苗接种是必不可少的,应在移植后三个月开始.
- 加强了干细胞移植后及时和完整的疫苗接种计划的重要性.
更多相关视频
08:52Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
17.2K
11:55Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
14.6K
相关概念视频
Cell-mediated Immune Responses
68.0K
Overview
68.0K
Tumor Immunotherapy
509
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
509
Bone Marrow Sampling and Transplants
323
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
323
Tissue Transplantation
354
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
354
Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
