脊柱运动障碍在NMOSD,MOGAD和异常性横侧肌炎:一个前性观察性研究
Hesham Abboud1,2,3, Rongyi Sun4, Nikhil Modak4
1Multiple Sclerosis and Neuroimmunology Program, University Hospitals Cleveland Medical Center, Bolwell, 5th Floor, 11100 Euclid Avenue, Cleveland, OH, 44106, USA. Hesham.abboud@uhhospitals.org.
Journal of neurology
|July 8, 2024
概括
脊柱运动障碍在NMOSD,MOGAD和ITM中很常见,性是最常见的. 纵向扩展性髓炎和AQP4-IgG是关键的危险因素.
科学领域:
- 神经免疫学 神经免疫学
- 神经学 神经学
- 运动障碍 运动障碍
背景情况:
- 追溯研究表明,神经omyelitis光学谱系障碍 (NMOSD) 中脊柱运动障碍,特别是强力的患病率很高.
- 之前没有任何前性研究研究过NMOSD,氨酸寡干细胞糖蛋白抗体相关疾病 (MOGAD) 和异常横向肌痛炎 (ITM) 的脊柱运动障碍.
研究的目的:
- 预期评估和比较患有NMOSD (有或没有AQP4-IgG),MOGAD和ITM的患者中脊柱运动障碍的患病率和特征.
- 为了确定与这些神经炎症状况中脊髓运动障碍的发展相关的预测因素.
主要方法:
- 在第三级神经免疫学诊所评估了63名脊髓脱髓 (不包括MS) 患者的队列.
- 患者完成了运动障碍调查,并接受了专注的神经学检查.
- 运动障碍在诊断组 (NMOSD有/没有AQP4-IgG,MOGAD,ITM) 之间以及有或没有非自愿运动的患者之间进行了比较.
主要成果:
- 运动障碍存在于73%的患者中,最常见的是AQP4-IgG (92%) 的NMOSD,最少的是MOGAD (57%).
- 调性 (57%),焦点 dystonia (25%) 和脊柱震 (16%) 是最常见的疾病.
- 纵向扩展性髓炎和AQP4-IgG血清阳性独立预测脊柱运动障碍,而MOG-IgG和非洲裔美国人种族与较低的风险有关.
结论:
- 脊髓运动障碍在非MS脊髓脱髓化障碍中非常普遍.
- 观察到的患病率超过了多发性硬化症 (MS) 和回顾性NMOSD研究中之前报告的患病率.
- 这些发现强调了脊柱运动障碍在这些疾病中的重大影响,并确定了关键的风险因素.
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