耳环环膜炎:细菌性还是真菌性? (一个案例系列)
概括
当细菌培养是负的时,真菌感染可能会导致性周周状炎. 甲基因组下一代测序 (mNGS) 识别了真菌,导致成功的抗真菌治疗和改善患者的治疗结果.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
背景情况:
- 耳环的补性周状腺炎是一种常见的疾病,有可能导致严重的形.
- 鉴定致病原体仍然具有挑战性,常规培养通常在近一半的病例中产生负面结果.
研究的目的:
- 研究元基因组下一代测序 (mNGS) 在诊断难以诊断的发热性周周状腺炎病例中的实用性.
- 突出菌病原体在带有负细菌培养的周周状炎中的潜在作用.
主要方法:
- 病例报告两名患有发热性周节炎的患者.
- 传统的微生物培养对病原体呈阴性.
- 甲基因组下一代测序 (mNGS) 用于病原体检测.
主要成果:
- 在这两位患者中,mNGS成功地发现了真菌感染.
- 在这两种情况下,抗真菌治疗导致了良好的预后和康复.
结论:
- 菌应被视为潜在的病原体,在经常出现负性细菌培养的桃体炎病例中.
- 下一代元基因组测序 (mNGS) 作为传统培养方法的宝贵补充,用于诊断具有挑战性的传染病.
- 早期应用mNGS可以指导适当的抗真菌治疗,改善患者的治疗结果.
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