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Updated: Jun 21, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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系统的孟德尔随机化探索出血性中风的可用药物基因

Lun-Zhe Yang1, Yong Yang1, Chuan Hong1

  • 1Department of Neurosurgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Molecular neurobiology
|July 8, 2024
PubMed
概括

这项研究使用了门德尔的随机化来识别与出血性中风相关的六个可用药物的基因. 抑制TNFSF12,SLC22A4和SPARC等特定基因可能会预防中风并降低相关的心血管风险.

关键词:
药物适应性基因是可以给予药物的基因.血流性中风是因为出血.门德尔的随机化基于总结数据的门德尔随机化.

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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