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低剂量hCG支持修改后的自然冷胚胎移植周期

Emre Pabuccu¹, Deniz Han Deniz², Aytekin Valadova³

¹Department of Obstetrics and Gynecology, Centrum Clinic ART Center, Ufuk University School of Medicine, Ankara, Turkey. emregpabuccu@gmail.com.

Reproductive sciences (Thousand Oaks, Calif.)

|July 8, 2024

概括

胚胎移植后的一次低剂量重组hCG注射可能会改善Letrozole诱导的修饰自然冷胚胎移植周期中的持续怀孕率. 这一发现表明,接受特定生育治疗的女性可能会受益.

科学领域:

生殖内分泌学生殖内分泌学
辅助生殖技术辅助生殖技术
临床产科和妇科临床产科和妇科

背景情况:

经过修改的自然冷胚胎移植 (mNC-FET) 周期使用莱特醇进行子宫内膜制备.
在FET周期中,质阶段的支持对于成功的植入和怀孕至关重要.
在mNC-FET中,额外的人类胆性淋巴激素 (hCG) 在支持质期的作用需要进一步研究.

研究的目的:

为了评估单次低剂量重组hCG注射后胚胎转移 (ET) 在莱特醇诱导的mNC-FET周期中所产生的效果.
为了确定这种干预措施是否会改善持续妊娠率 (OPRs) 与标准的质支持相比.

主要方法:

一项观察性,准随机研究包括154名接受莱特醇诱导的mNC-FET的妇女.
排卵是由重组hCG触发的;质支持包括丁多.
干预组在ET后的第3天接受了额外的3250 IU重组hCG;对照组没有.

主要成果:

与对照组 (33.6%) (p=0.03) 相比,hCG组的持续怀孕率 (46.7%) 显着更高.
人口统计数据,血清孕激素水平和胚胎移植数量在两组之间是可比的.
没有观察到基线特征的显著差异,支持干预的影响.

结论:

胚胎移植后的一次低剂量重组hCG注射可能会在莱特醇诱导的mNC-FET周期中增加正在进行的怀孕率.
这种干预可以成为在特定FET协议中对质阶段支持的宝贵补充.
需要进一步的研究来证实这些发现,并阐明其确切的作用机制.

关键词:

冷的胚胎胚胎是什么流体阶段流体阶段持续的怀孕率持续的怀孕率孕激素 (Progesterone) 是一种激素.这是一个高CG.

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