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Updated: Jun 21, 2025

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一个修改通过mTORC1信号调节HSC维护和自我更新

Hongna Zuo1, Aiwei Wu1, Mingwei Wang1

  • 1Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China.

Nature communications
|July 8, 2024
PubMed
概括

TRMT6蛋白通过控制蛋白质翻译来调节造血干细胞 (HSC) 功能. 删除TRMT6通过激活mTORC1信号来破坏HSC的自我更新,突出显示HSC恒温的新机制.

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