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Updated: Jun 21, 2025

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
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基因编码的Nδ-维尼尔希斯提丁用于酶催化中心进化的进化

Haoran Huang1, Tao Yan1, Chang Liu1

  • 1Department of Chemistry, Research Center for Chemical Biology and Omics Analysis, College of Science, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, 518055, China.

Nature communications
|July 8, 2024
PubMed
概括

研究人员设计了非自然氨基酸Nδ-Vinyl Histidine (δVin-H),用于增强蛋白质催化. 这种遗传密码的扩展通过修改催化胺残留物来改善酶的性能.

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