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Updated: Jun 21, 2025

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
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评估和设计用于编程基因组编辑的IscB-ωRNA系统.

Hao Yan1,2, Xiaoqing Tan3, Siyuan Zou1,2

  • 1Department of Chemistry, The University of Chicago, Chicago, IL, USA.

Nature chemical biology
|July 8, 2024
PubMed
概括

研究人员设计了IscB,一个OMEGA RNA (ωRNA) 引导的内核酶,用于在人体细胞中增强体内基因组编辑. 改进的OgeuIscB系统显示了DNA结合和编辑效率的提高,使其成为基因编辑应用的强大工具.

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