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抗HBV核酸类似物E-CFCP-TP与逆转录酶活性部位的异常结合减弱了耐药突变的影响

Yoshiaki Yasutake1,2, Shin-Ichiro Hattori3, Hiroki Kumamoto4

  • 1Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, 062-8517, Japan. y-yasutake@aist.go.jp.

Scientific reports
|July 8, 2024
PubMed
概括

一种新型核酸类比物,E-CFCP,对具有乙型肝炎病毒 (HBV) 相关突变的人类免疫缺陷病毒1型 (HIV-1) 具有很高的敏感性. 这一发现有助于设计针对HIV-1和HBV的新抗病毒药物.

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