经直流刺激引起的运动皮质连接的变化与缺血性中风后的运动增益有关
Chunfang Wang1,2,3, Xiangli Yang4, Dan Guo1,2,3
1Rehabilitation Medical Department, Tianjin Union Medical Centre, Tianjin, China.
Scientific reports
|July 8, 2024
概括
超直流刺激 (tDCS) 影响大脑连接不同根据组装. 阳极tDCS增加了连接性,以获得更好的运动收益,而正极tDCS通过降低连接性来改善功能.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 跨直流刺激 (tDCS) 在中风后的运动恢复中显示出不同的结果.
- 皮层连接性变化与运动增长和可塑性有关,但对连接性的tDCS影响尚不清楚.
研究的目的:
- 调查tDCS诱导的运动皮质连接性变化和中风后的运动增益之间的关系.
- 探索不同的tDCS组装如何影响大脑连接和功能恢复.
主要方法:
- 一个单盲,随机,交叉研究,涉及四个tDCS组装 (阳极,阴极,双边,假) 在主要运动皮层 (M1).
- 脑电图 (EEG) 和杰布森-泰勒手部功能测试 (JTT) 用于干预前后的测量.
- 动力皮层连接性被评估使用β频段连贯性,M1作为种子区域;动力增益被测量为JTT完成时间.
主要成果:
- 基线功能连接,运动障碍和中风后持续时间都与之相关.
- 较高的ipsilesional M1前时连接与更好的基线运动状态相关,并与阳极tDCS得到改善.
- 低收缩的M1-正面-中心连接与更好的基线运动状态相关,并与阴极tDCS得到改善.
结论:
- 基于EEG的运动皮质连接与中风特征相关,如运动障碍和持续时间.
- 阳极和正极tDCS通过改变皮质连接以不同的模式来诱导运动收益.
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