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癌症有机体2.0:模拟瘤免疫微环境的复杂性

Roel Polak^1,2, Elisa T Zhang¹, Calvin J Kuo³

¹Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA.

Nature reviews. Cancer

|July 8, 2024

概括

三维器官模型准确地模仿瘤微环境 (TME) 和其免疫相互作用. 这些先进的模型为改善癌症免疫疗法的疗效和开发个性化医疗策略提供了新的途径.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

瘤发育涉及癌细胞和瘤微环境 (TME) 之间的复杂相互作用.
目前针对TME的癌症免疫疗法具有可变的疗效,并且经常受到耐药性的限制.
需要准确的实验模型来回顾患者特定的瘤免疫微环境.

研究的目的:

审查当前和新兴的3D瘤有机体模型.
要突出有机体在捕捉TME的关键免疫特征的能力.
讨论有机体在理解瘤免疫,药物开发和精密医学中的应用.

主要方法:

关于3D瘤有机体模型的现有文献的综述.
对有机体平台的分析,这些平台包含了TME的免疫成分.
讨论在免疫疗法研究中使用有机体的实验策略.

主要成果:

3D瘤器官有效地模拟了TME复杂的细胞和免疫架构.
有机器人可以回顾患者特定的瘤生物学和对免疫治疗的反应.
这些模型为免疫疗法耐药性的机制提供了洞察力.

结论:

3D瘤器官是促进癌症免疫治疗研究的强大工具.
器官技术通过使患者特定的药物测试成为可能,促进了个性化医疗方法.
基于器官的研究对改善免疫瘤学的患者选择和治疗策略具有重大前景.

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