血小板与高密度脂蛋白胆固醇的比率与高尿素血的相关性
Laisha Yan1, Xiaoyan Hu1, Shanshan Wu1
1Department of Cardio Surgery Intensive Care Unit, Ningbo Medical Centre Li Huili Hospital, Ningbo, China.
Scientific reports
|July 8, 2024
概括
血小板/高密度脂蛋白 (PHR) 的比率与高尿血症的风险更高有关. 这一发现表明PHR可能是预测高尿素血症发展的新生物标志物.
科学领域:
- 代谢障碍和心血管健康.
- 在临床研究中发现生物标志物.
背景情况:
- 血小板/高密度脂蛋白 (PHR) 的比率表明炎症和高凝固性.
- PHR与非酒精性脂肪性肝病 (NAFLD) 和代谢综合征 (MetS) 有关.
- PHR和高尿素血的关系仍未得到研究.
研究的目的:
- 为了检查PHR和高尿血的相关性.
- 为了确定PHR是否可以作为高尿血的预测生物标志物.
主要方法:
- 使用NHANES数据 (2007-2016) 的横截面研究.
- PHR计算为血小板计数除以HDL-C水平.
- 进行了多变量逻辑回归,通用添加模型和子组分析.
主要成果:
- 高尿路血症的患病率为18.56%.
- 在PHR和高尿血风险之间发现了显著的正相关性 (OR1.11,95%CI1.08-1.14).
- 这种关联在各种人口和临床子组中是一致的.
结论:
- PHR与高尿素血症正相关.
- PHR可能会作为预测高尿路血症的新生物标志物.
- 针对PHR的干预措施可能会降低高尿路血症的发生率.
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