患有肺腺癌和地面玻璃不透明性的年轻和老年患者之间的不同临床病理特征

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Xingbing Lu¹, Yuzuo Chen¹, Yuxiao Li²

¹Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Scientific reports

|July 8, 2024

概括

与老年患者相比,被诊断患有地面玻璃不透明 (GGO) 肺腺癌的年轻人表现出明显的病理特征. 尽管存在差异,但年轻患者表现出很好的3年生存率,这表明预后有利.

科学领域:

肺部病理学肺部病理学
在瘤学瘤学.
胸部外科手术胸部外科手术

背景情况:

计算机断层扫描查增加了年轻成年人肺部地面玻璃不透明 (GGO) 的诊断.
转基因组分肺结节的恶性发病率可能高达63%.
年轻的癌症患者具有独特的特征,由于环境变异原体暴露有限.

研究的目的:

为了比较GGO相关肺腺癌 (GGO-LUAD) 的年轻 (<40岁) 和老年 (>40岁) 患者之间的临床病理特征.
评估基于年龄的瘤大小,病理特征和预后的差异.

主要方法:

对203名接受视频辅助胸腔镜手术的患者进行了回顾性审查,以治疗GGO组件结节 (2018年1月 - 2020年4月).
患者分为两个组:≤40岁 (n=103) 和>40岁 (n=100).
对临床病理特征的分析,包括性别,吸烟状态,瘤大小,病理和预后;用于比较的单变量分析.

主要成果:

年龄组之间的基线特征 (性别,吸烟,位置) 没有显著差异.
年轻患者更频繁地患有<1厘米的瘤,而老年患者主要患有>2厘米的瘤.
在老年人群中,侵入性腺癌的平均百分比较高;年轻和老年患者表现出类似的亚型,但差异程度不同 (p<0.001).
年轻组的三年整体存活率 (OS) 和无复发存活率 (RFS) 分别为100%和99.03%,年长组为99%和98%.

结论:

年轻患者患有恶性肺结节和GGOs存在明显的病理亚型.
年龄显著影响了GGO患者的临床病理学特征.
患有恶性肺结节和GGO的年轻患者表现出高度令人满意的3年预后.

关键词:

临床特征临床特征肺部腺癌细胞瘤是什么肺部地面玻璃的不透明度 (GGO)

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