多王国和功能性肠道微生物群标志物用于自闭症谱系障碍
Qi Su1,2, Oscar W H Wong3,4, Wenqi Lu1,2
1Microbiota I-Center (MagIC), Hong Kong SAR, China.
Nature microbiology
|July 8, 2024
概括
研究人员探索了肠道微生物群.
科学领域:
- 微生物组研究的研究.
- 神经发育障碍 神经发育障碍
- 转基因组学是指转基因组学.
背景情况:
- 以前关于自闭症谱系障碍 (ASD) 的研究主要集中在肠道细菌上.
- 在ASD中,古生物,真菌,病毒和整体肠道微生物组的作用仍然在很大程度上未被探索.
研究的目的:
- 调查患有ASD的儿童肠道微生物组的变化,包括古生物,真菌,病毒和功能途径.
- 评估肠道微生物群标志物对ASD的诊断潜力.
主要方法:
- 来自1,627名患有或没有自闭症的儿童 (1-13岁) 便样本的基因组测序.
- 对古生物,细菌,真菌,病毒,微生物基因和代谢途径的综合分析.
- 开发了机器学习模型,以区分患有自闭症和没有自闭症的儿童.
主要成果:
- 在患有自闭症儿童的14种古生物,51种细菌,7种真菌,18种病毒,27种微生物基因和12种代谢途径中观察到显著的变化.
- 单个王国面板实现了ASD差异化曲线下的面积 (AUC) 为0.680.87.
- 一个多领域和功能性标记面板显示出卓越的诊断准确性 (AUC 0.91),由ubiquinol-7和胺二酸盐生物合成途径驱动.
结论:
- 肠道微生物群,包括多个王国和功能途径,显示出ASD儿童的显著变化.
- 多王国和功能性肠道微生物群标记物有望成为ASD的非侵入性诊断工具.
- 这些发现扩大了我们对ASD肠道微生物组的细菌关联的理解.
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